Clockiebox,
In addition to what Monika said, you may consider which is worse, to scale down to have all Artboards fit into the 16,384 x 16,384 points Workspace (and scale up in connexion with printing, which is relatively straightforward with Acrobat/Reader), or to have Artboards spread over multiple Layers/documents.
If you scale down, remember to scale up Effect>Document Raster Effects Settings resolution and raster image resolution (using the reverse scaling factor).